About   Help   FAQ
Cyp1atm1.1Bra
Targeted Allele Detail
Summary
Symbol: Cyp1atm1.1Bra
Name: cytochrome P450, family 1, subfamily a cluster; targeted mutation 1.1, Christopher A Bradfield
MGI ID: MGI:3840319
Synonyms: Cyp1a1/Cyp1a2tm1.1Bra, DREC-
Gene: Cyp1a  Location: unknown  Genetic Position: Chr9, Syntenic
Increased liver inflammation and decreased hydropic degeneration in MGI:3840320/MGI:3840320 mice in response to dioxin-induced toxicity

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147150
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsAn frt flanked neo cassette followed by a loxP site were inserted upstream and a second loxP site was inserted downstream of a cluster of 7 dioxin responsive elements (DRE). These DREs regulate expression of both Cyp1a1 and Cyp1a2. The neo cassette and DRE cluster were then removed by Flp and Cre mediated recombination respectively. (J:147150)
Generation of the MGI:3840320 allele
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp1a Mutation:  0 strains or lines available
References
Original:  J:147150 Nukaya M, et al., The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4923-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory