Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pak1tm1Cher
Name:	p21 (RAC1) activated kinase 1; targeted mutation 1, Jonathan Chernoff
MGI ID:	MGI:3834675
Gene:	Pak1  Location: Chr7:97437748-97561588 bp, + strand  Genetic Position: Chr7, 53.57 cM
Alliance:	Pak1tm1Cher page

Germline Transmission:	Earliest citation of germline transmission: J:142439
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector replaced the coding sequence of the p21-binding domain and the inhibitory domain with a neomycin resistance gene in the anti-sense orientation. A lack of protein was confirmed in homozygote bone marrow-derived mast cells by immunoblot assays. (J:142439, J:145444)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pak1 Mutation:	36 strains or lines available

Original:	J:142439 McDaniel AS, et al., Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood. 2008 Dec 1;112(12):4646-54
All:	30 reference(s)