Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hbb-ytm2.1Fier
Name:	hemoglobin Y, beta-like embryonic chain; targeted mutation 2.1, Steven Fiering
MGI ID:	MGI:3834619
Synonyms:	deltaEy
Gene:	Hbb-y  Location: Chr7:103500961-103502414 bp, - strand  Genetic Position: Chr7, 54.85 cM
Alliance:	Hbb-ytm2.1Fier page

Germline Transmission:	Earliest citation of germline transmission: J:145362
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 1.1 kb of DNA containing the promoter region, exon1, and exon2 was replaced with a floxed PGK-hygro selection cassette in ES cells already containing the targeted allele Hbb-bh1 allele. The selection cassettes in the two genes were subsequently excised by breeding mice to CMV-cre transgenic mice. This allele is only found in conjunction with Hbb-bh1. (J:145362)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hbb-y Mutation:	4 strains or lines available

Original:	J:145362 Hu X, et al., Transcriptional interference among the murine beta-like globin genes. Blood. 2007 Mar 1;109(5):2210-6
All:	1 reference(s)