Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mep1atm1Bond
Name:	meprin 1 alpha; targeted mutation 1, Judith S Bond
MGI ID:	MGI:3833886
Gene:	Mep1a  Location: Chr17:43785215-43813703 bp, - strand  Genetic Position: Chr17, 19.73 cM, cytoband C1-D1
Alliance:	Mep1atm1Bond page

Germline Transmission:	Earliest citation of germline transmission: J:145147
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette with an in-frame stop codon was inserted into the zinc-catalytic center encoded by exon 7. In the process, 140 bp were deleted at the targeting site. End-point PCR of kidney mRNA demonstrated the absence of transcription. Absence of protein product was indicated by immunoblot analysis of urine. (J:145147)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mep1a Mutation:	46 strains or lines available

Original:	J:145147 Banerjee S, Meprin Metalloproteases Modulate Intestinal Host Response. PhD Thesis - Pennsylvania State University. 2008;
All:	15 reference(s)