Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sac3d1tm1Hnaka
Name:	SAC3 domain containing 1; targeted mutation 1, Hideaki Nakajima
MGI ID:	MGI:3831538
Synonyms:	SHD1-
Gene:	Sac3d1  Location: Chr19:6166030-6168680 bp, - strand  Genetic Position: Chr19, 4.34 cM
Alliance:	Sac3d1tm1Hnaka page

Germline Transmission:	Earliest citation of germline transmission: J:144601
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A SpeI-NotI fragment containing the proximal promoter and the upstream-portion of exon 1 was replaced with neomycin resistance gene. Correct targeting was confirmed by Southern blotting. Gene inactivation was confirmed by a failure to detect protein product in immunoblot analysis of thymocyte nuclear extracts collected from homozgytoes. (J:144601)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sac3d1 Mutation:	12 strains or lines available

Original:	J:144601 Nakajima H, et al., SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription. Blood. 2009 Jan 29;113(5):1027-36
All:	1 reference(s)