Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bag3tm1.1Jhl
Name:	BCL2-associated athanogene 3; targeted mutation 1.1, Jeong-Hwa Lee
MGI ID:	MGI:3831334
Synonyms:	Bis-
Gene:	Bag3  Location: Chr7:128125340-128148705 bp, + strand  Genetic Position: Chr7, 70.26 cM
Alliance:	Bag3tm1.1Jhl page

Germline Transmission:	Earliest citation of germline transmission: J:144416
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Male mice carrying the Bag3tm1Jhl allele, which has exon 4 of the gene locus flanked by loxP sites, were bred with cre transgenic mice to excise exon 4 from the germline. Gene inactivation was confirmed in tail and liver extracts by failure to detect protein in immunoblot assays using three different antibodies raised against whole, COOH-terminal, and NH2-terminal peptides. (J:144416)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bag3 Mutation:	31 strains or lines available

Original:	J:144416 Youn DY, et al., Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1349-57
All:	6 reference(s)