Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il17ftm1Yiw
Name:	interleukin 17F; targeted mutation 1, Yoichiro Iwakura
MGI ID:	MGI:3830035
Synonyms:	IL-17F
Gene:	Il17f  Location: Chr1:20847370-20855498 bp, - strand  Genetic Position: Chr1, 6.49 cM
Alliance:	Il17ftm1Yiw page

Germline Transmission:	Earliest citation of germline transmission: J:143719
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This gene locus lies within 60 kb of the highly homologous gene locus Il17A. In order to generate a double mutant, ES cells heterozygote for the Il17atm1Yiw null allele were retargeted with a second vector to the Il17f locus. A hygromycin resistance gene replaced exons 2 and 3 of the allele that was in trans with the Il17atm1Yiw allele. The two mutant loci were bred apart and gene inactivation of just the Il17f allele was confirmed by RT-PCR of activated splenocytes collected from homozygote mice. (J:143719)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17f Mutation:	27 strains or lines available

Original:	J:143719 Ishigame H, et al., Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan;30(1):108-19
All:	16 reference(s)