Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tm7sf2tm1Fdp
Name:	transmembrane 7 superfamily member 2; targeted mutation 1, Forbes D Porter
MGI ID:	MGI:3829354
Synonyms:	Dhcr14delta4-7
Gene:	Tm7sf2  Location: Chr19:6112851-6117880 bp, - strand  Genetic Position: Chr19, 4.34 cM, cytoband A
Alliance:	Tm7sf2tm1Fdp page

Germline Transmission:	Earliest citation of germline transmission: J:143838
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All sequence from intron 4 through intron 6 is replaced with a PGK-neomycin resistance cassette. Quantitative PCR confirmed the absence of expression. (J:143838)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tm7sf2 Mutation:	30 strains or lines available

Original:	J:143838 Wassif CA, et al., HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency. Hum Mol Genet. 2007 May 15;16(10):1176-87
All:	1 reference(s)