Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcamtm1Jhm
Name:	basal cell adhesion molecule; targeted mutation 1, Jeffrey H Miner
MGI ID:	MGI:3822736
Gene:	Bcam  Location: Chr7:19490063-19504457 bp, - strand  Genetic Position: Chr7, 9.94 cM
Alliance:	Bcamtm1Jhm page

Germline Transmission:	Earliest citation of germline transmission: J:142595
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A 2 kb fragment containing exons 11 though 13 was deleted resulting in the absence of 142 amino acids of the fifth Ig domain, the transmembrane domain, and the first 20 amino acids of the cytoplasmic tail. Splicing from exon 10 to 14 results in an out of frame transcript. The absence of protein exppression was confirmed by immunohistochemistry on neuromuscular junctions. (J:142595)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcam Mutation:	35 strains or lines available

Original:	J:142595 Nishimune H, et al., Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction. J Cell Biol. 2008 Sep 22;182(6):1201-15
All:	2 reference(s)