Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Myh11tm2Peri Name: myosin, heavy polypeptide 11, smooth muscle; targeted mutation 2, Muthu Periasamy MGI ID: MGI:3821724 Synonyms: SM2- Gene: Myh11  Location: Chr16:14012392-14109227 bp, - strand  Genetic Position: Chr16, 9.71 cM Alliance: Myh11tm2Peri page

Myh11tm2Peri/Myh11tm2Peri mice exhibit segmental distention of alimentary tract, retention of urine in renal pelvis/bladder and development of end-stage hydronephrosis Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:142230
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 41 was replaced with a neo cassette. The absence of isoform SM2 and reduced presence of isoform SM1 was confirmed by western blot analysis on bladder extracts. (J:142230)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh11 Mutation:	93 strains or lines available

Original:	J:142230 Chi M, et al., Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18614-8
All:	1 reference(s)