Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pak6tm1Amin
Name:	p21 (RAC1) activated kinase 6; targeted mutation 1, Audrey Minden
MGI ID:	MGI:3821622
Gene:	Pak6  Location: Chr2:118493784-118528501 bp, + strand  Genetic Position: Chr2, 59.41 cM
Alliance:	Pak6tm1Amin page

Germline Transmission:	Earliest citation of germline transmission: J:141962
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All of exon 1 and part of exon 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:141962)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pak6 Mutation:	27 strains or lines available

Original:	J:141962 Nekrasova T, et al., Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Dev Biol. 2008 Oct 1;322(1):95-108
All:	2 reference(s)