Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Telo2tm1.1Tdl
Name:	telomere maintenance 2; targeted mutation 1.1, Titia de Lange
MGI ID:	MGI:3819391
Synonyms:	Tel2DEL
Gene:	Telo2  Location: Chr17:25318544-25334941 bp, - strand  Genetic Position: Chr17, 12.53 cM, cytoband A3.3
Alliance:	Telo2tm1.1Tdl page

Germline Transmission:	Earliest citation of germline transmission: J:141633
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Transient cre expression in ES cells was used to remove the floxed exon 3 and the neo cassette. This deletion results in a frame shift and premature termination of translation at amino acid 168 of 840. A two-fold reduction in protein expression levels was confirmed by western blot analysis on embryonic fibroblasts heterozygous for the allele. (J:141633)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Telo2 Mutation:	33 strains or lines available

Original:	J:141633 Takai H, et al., Tel2 regulates the stability of PI3K-related protein kinases. Cell. 2007 Dec 28;131(7):1248-59
All:	1 reference(s)