Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arhgef12tm1Soff
Name:	Rho guanine nucleotide exchange factor 12; targeted mutation 1, Stefan Offermanns
MGI ID:	MGI:3819185
Gene:	Arhgef12  Location: Chr9:42875138-43017069 bp, - strand  Genetic Position: Chr9, 24.14 cM, cytoband B
Alliance:	Arhgef12tm1Soff page

Germline Transmission:	Earliest citation of germline transmission: J:141641
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first coding exon (nucleotides 8-307 of NM_027144) and part of the 5' UTR were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver and other organ extracts. (J:141641)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef12 Mutation:	89 strains or lines available

Original:	J:141641 Wirth A, et al., G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med. 2008 Jan;14(1):64-8
All:	2 reference(s)