Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Txniptm1.1Rlee
Name:	thioredoxin interacting protein; targeted mutation 1.1, Richard T Lee
MGI ID:	MGI:3818744
Synonyms:	Txnipnull
Gene:	Txnip  Location: Chr3:96465273-96469173 bp, + strand  Genetic Position: Chr3, 41.93 cM, cytoband F2.2
Alliance:	Txniptm1.1Rlee page

Germline Transmission:	Earliest citation of germline transmission: J:141487
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was deleted via cre mediated recombination, Northern and western blot analysis confirmed the absence of mRNA and protein expression in the heart. (J:141487)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Txnip Mutation:	48 strains or lines available

Original:	J:141487 Yoshioka J, et al., Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 2007 Dec 7;101(12):1328-38
All:	8 reference(s)