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Sirt1tm1.1Cxd
Targeted Allele Detail
Summary
Symbol: Sirt1tm1.1Cxd
Name: sirtuin 1; targeted mutation 1.1, Chu-Xia Deng
MGI ID: MGI:3812143
Synonyms: Sirt1-
Gene: Sirt1  Location: Chr10:63154784-63174814 bp, - strand  Genetic Position: Chr10, 32.57 cM
Alliance: Sirt1tm1.1Cxd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140089
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination was used to remove the neo cassette and exons 5 and 6. The absence of protein expression was confirmed by western blot analysis on embryo extracts. (J:140089)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Sirt1tm1.1Cxd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt1 Mutation:  78 strains or lines available
References
Original:  J:140089 Wang RH, et al., Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008 Oct 7;14(4):312-23
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory