Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trpc3tm1.1Akon
Name:	transient receptor potential cation channel, subfamily C, member 3; targeted mutation 1.1, Arthur Konnerth
MGI ID:	MGI:3810122
Synonyms:	Trpc3-
Gene:	Trpc3  Location: Chr3:36674626-36744276 bp, - strand  Genetic Position: Chr3, 17.93 cM, cytoband B
Alliance:	Trpc3tm1.1Akon page

Germline Transmission:	Earliest citation of germline transmission: J:139695
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was introduced into intron 6 and a floxed PGK-neo cassette was inserted into intron 7. The selection cassette was removed from properly targeted ES cells leaving exon 7 floxed. Mice with the floxed exon 7 were crossed to cre expressing mice to create the knockout allele. (J:139695)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpc3 Mutation:	56 strains or lines available

Original:	J:139695 Hartmann J, et al., TRPC3 channels are required for synaptic transmission and motor coordination. Neuron. 2008 Aug 14;59(3):392-8
All:	55 reference(s)