Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Csrp2tm1Rawe
Name:	cysteine and glycine-rich protein 2; targeted mutation 1, Ralf Weiskirchen
MGI ID:	MGI:3809532
Gene:	Csrp2  Location: Chr10:110756037-110775375 bp, + strand  Genetic Position: Chr10, 57.84 cM
Alliance:	Csrp2tm1Rawe page

Germline Transmission:	Earliest citation of germline transmission: J:138969
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neo cassette was inserted into exon 4 at nucleotide 7292 via homologous recombination. Northern blot and quantitative RT-PCR confirmed a 50% reduction in wild-type transcript and detected an aberrant message consisting of a splicing between exon 3 and the downstream neo cassette/exon 4 boundary in heterozygotes. Western blot analysis of kidney homogenates from homozygotes confirmed the absence of protein. (J:138969)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Csrp2 Mutation:	95 strains or lines available

Original:	J:138969 Sagave JF, et al., Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure. BMC Dev Biol. 2008;8:80
All:	1 reference(s)