Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Sgpp1tm1(KOMP)Vlcg Name: sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene MGI ID: MGI:3808500 Synonyms: Sgpp1tm1Vlcg Gene: Sgpp1  Location: Chr12:75761023-75782503 bp, - strand  Genetic Position: Chr12, 32.95 cM Alliance: Sgpp1tm1(KOMP)Vlcg page IMPC: Sgpp1 gene page

Sgpp1tm1(KOMP)Vlcg/Sgpp1tm1(KOMP)Vlcg pups exhibit focal desquamation and abnormal epidermal histology Show the 3 phenotype image(s) involving this allele.

Mutant Cell Lines:	10963C-C9, 10963C-E3, 10963C-F1, 10963C-G12
Germline Transmission:	Earliest citation of germline transmission: J:199597
Parent Cell Line:	VGB6 (ES Cell)
Strain of Origin:	C57BL/6NTac
Project Collection:	KOMP-Regeneron

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1   Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 19624bp between positions 75762711-75782334 of Chromosome 12 (Build GRCm39). The lacZ and neomycin resistance cassette replaced the entire coding region from exon 1 to 3. (J:136110, J:199597)

Generation of the Sgpp1tm1(KOMP)Vlcg allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Sgpp1 Mutation:	25 strains or lines available

Original:	J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:	3 reference(s)