Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Spi1tm1.1Rpd
Name:	Spi-1 proto-oncogene; targeted mutation 1.1, Rodney P DeKoter
MGI ID:	MGI:3806995
Synonyms:	Sfpi1Blac
Gene:	Spi1  Location: Chr2:90912750-90946104 bp, + strand  Genetic Position: Chr2, 50.44 cM, cytoband E3
Alliance:	Spi1tm1.1Rpd page

Germline Transmission:	Earliest citation of germline transmission: J:138501
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Hypomorph, Reporter) Mutation:    Insertion   Mutation details: Germ line, cre mediated recombination was used to remove the neo cassette leaving the beta-lactamase intact. This is a hypomorphic allele. (J:138501)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spi1 Mutation:	27 strains or lines available

Original:	J:138501 Kamath MB, et al., Dose-dependent repression of T-cell and natural killer cell genes by PU.1 enforces myeloid and B-cell identity. Leukemia. 2008 Jun;22(6):1214-25
All:	1 reference(s)