Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppme1tm1Crv
Name:	protein phosphatase methylesterase 1; targeted mutation 1, Benjamin J Cravatt
MGI ID:	MGI:3804708
Synonyms:	PME-1-
Gene:	Ppme1  Location: Chr7:99975944-100021103 bp, - strand  Genetic Position: Chr7, 54.35 cM, cytoband F1
Alliance:	Ppme1tm1Crv page

Germline Transmission:	Earliest citation of germline transmission: J:138002
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 7 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain, heart and liver extracts. (J:138002)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppme1 Mutation:	23 strains or lines available

Original:	J:138002 Ortega-Gutierrez S, et al., Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice. PLoS One. 2008;3(7):e2486
All:	4 reference(s)