Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cremtm1.1Endo
Name:	cAMP responsive element modulator; targeted mutation 1.1, Shogo Endo
MGI ID:	MGI:3802585
Gene:	Crem  Location: Chr18:3266048-3337748 bp, - strand  Genetic Position: Chr18, 2.14 cM, cytoband A
Alliance:	Cremtm1.1Endo page

Germline Transmission:	Earliest citation of germline transmission: J:137666
Parent Cell Line:	MS12 (ES Cell)
Strain of Origin:	C57BL/6NSlc

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon P2 and a neo cassette with a 3' loxP site was inserted downstream of exon P2. Transient cre expression in fertilized oocytes was used to remove the neo cassette and exon P2. (J:137666)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crem Mutation:	38 strains or lines available

Original:	J:137666 Kojima N, et al., Inducible cAMP early repressor acts as a negative regulator for kindling epileptogenesis and long-term fear memory. J Neurosci. 2008 Jun 18;28(25):6459-72
All:	4 reference(s)