Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ranbp2tm1.1Jvd
Name:	RAN binding protein 2; targeted mutation 1.1, Jan M A van Deursen
MGI ID:	MGI:3800899
Gene:	Ranbp2  Location: Chr10:58282674-58329977 bp, + strand  Genetic Position: Chr10, 29.34 cM
Alliance:	Ranbp2tm1.1Jvd page

Germline Transmission:	Earliest citation of germline transmission: J:137482
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Germ line, cre-mediated recombination was used to remove exon 3. Lack of protein expression from this allele was confirmed by western blot analysis on heterozygous mouse embryonic fibroblast extracts. (J:137482)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Ranbp2tm1.1Jvd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ranbp2 Mutation:	114 strains or lines available

Original:	J:137482 Dawlaty MM, et al., Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell. 2008 Apr 4;133(1):103-15
All:	2 reference(s)