Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc12a1tm1Haca
Name:	solute carrier family 12, member 1; targeted mutation 1, Hayo Castrop
MGI ID:	MGI:3795217
Synonyms:	NKCC2B-
Gene:	Slc12a1  Location: Chr2:124994430-125071922 bp, + strand  Genetic Position: Chr2, 61.23 cM
Alliance:	Slc12a1tm1Haca page

Germline Transmission:	Earliest citation of germline transmission: J:135710
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4B was replaced with a STOP and floxed neo cassette. Germ line, cre-mediated recombination was used to remove the neo cassette. Expression of the A and F alternate transcripts but not the B transcript was confirmed by RT-PCR. (J:135710)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc12a1 Mutation:	55 strains or lines available

Original:	J:135710 Oppermann M, et al., Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter. J Am Soc Nephrol. 2006 Aug;17(8):2143-52
All:	2 reference(s)