Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gata6tm3.1Sad
Name:	GATA binding protein 6; targeted mutation 3.1, Stephen A Duncan
MGI ID:	MGI:3793425
Synonyms:	Gata4-Gata6-
Gene:	Gata6  Location: Chr18:11052510-11085636 bp, + strand  Genetic Position: Chr18, 5.63 cM
Alliance:	Gata6tm3.1Sad page

Germline Transmission:	Earliest citation of germline transmission: J:135185
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 and 4 were floxed and cre-mediated recombination was used to remove the exons as well as the selection cassette. Gene targeting was performed ES cells that were homozygous for Gata4tm1.2Sad. The absence of Gata 4 and 6 transcripts was confirmed by RT-PCR on embryoid body extracts. (J:135185)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

23 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata6 Mutation:	32 strains or lines available

Original:	J:135185 Zhao R, et al., Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol. 2008 May 15;317(2):614-9
All:	3 reference(s)