Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mfap2tm1Mech
Name:	microfibrillar-associated protein 2; targeted mutation 1, Robert P Mecham
MGI ID:	MGI:3790750
Synonyms:	MAGP1-
Gene:	Mfap2  Location: Chr4:140737735-140743286 bp, + strand  Genetic Position: Chr4, 73.31 cM, cytoband D3-E1
Alliance:	Mfap2tm1Mech page

Germline Transmission:	Earliest citation of germline transmission: J:134343
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 3 to 6, which encode a portion of the signal peptide and nearly half of the coding sequence of the gene, were deleted by homologous recombination. Analysis of the founder lines confirmed that the targeting strategy had successfully given rise to the expected mutant allele. (J:134343)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mfap2 Mutation:	13 strains or lines available

Original:	J:134343 Werneck CC, et al., Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Blood. 2008 Apr 15;111(8):4137-44
All:	8 reference(s)