Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Del(4Cdkn2a-Cdkn2b)1Brn
Name:	deletion, Chr 4, Anton Berns 1
MGI ID:	MGI:3790457
Synonyms:	Cdkn2a/Cdkn2btm1Brn, Cdkn2a/Cdkn2btm1Nki
Gene:	Del(4Cdkn2a-Cdkn2b)1Brn  Location: unknown  Genetic Position: Chr4, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:125189
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion, Intragenic deletion   Del(4Cdkn2a-Cdkn2b)1Brn involves 2 genes/genome features (Cdkn2a, Cdkn2b) View all   Mutation details: Cre-mediated recombination in ES cells with a loxP site and a stop codon inserted in exon 1 alpha of Cdkn2a and with exons 1 and 2 of Cdkn2b replaced with a PGK-hyg cassette as well as a 5' loxP site resulted in a deletion encompassing the promoter of Cdkn2b and the 5' half of the Cdkn2a exon 1a. The absence of p15Ink4b, p16Ink4a and p19Arf protein products was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:125189)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(4Cdkn2a-Cdkn2b)1Brn Mutation:	0 strains or lines available

Original:	J:125189 Krimpenfort P, et al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature. 2007 Aug 23;448(7156):943-6
All:	1 reference(s)