Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Masp1tm1Tefu
Name:	MBL associated serine protease 1; targeted mutation 1, Teizo Fujita
MGI ID:	MGI:3790322
Synonyms:	MASP1/3-
Gene:	Masp1  Location: Chr16:23268167-23339565 bp, - strand  Genetic Position: Chr16, 14.23 cM, cytoband B2-B3
Alliance:	Masp1tm1Tefu page

Germline Transmission:	Earliest citation of germline transmission: J:134537
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a neo cassette. The absence of both major protein isoform products was confirmed by western blot analysis. (J:134537)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Masp1 Mutation:	45 strains or lines available

Original:	J:134537 Takahashi M, et al., Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway. J Immunol. 2008 May 1;180(9):6132-8
All:	10 reference(s)