Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Upf2tm1.1Btp
Name:	UPF2 regulator of nonsense transcripts homolog (yeast); targeted mutation 1.1, Bo Torben Porse
MGI ID:	MGI:3790199
Synonyms:	Upf2delta
Gene:	Upf2  Location: Chr2:5956280-6061514 bp, + strand  Genetic Position: Chr2, 3.62 cM
Alliance:	Upf2tm1.1Btp page

Germline Transmission:	Earliest citation of germline transmission: J:134765
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 2 (containing the start methionine codon) and 3 were removed by germ line, cre mediated recombination. This allele is expected to produce a functionally inactive protein lacking several important domains including the N-terminal domain required for Upf1 interaction and nonsense-mediated mRNA decay (NMD). (J:134765)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

156076 assay results 2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Upf2 Mutation:	62 strains or lines available

Original:	J:134765 Weischenfeldt J, et al., NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev. 2008 May 15;22(10):1381-96
All:	3 reference(s)