Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pla2g6tm1Tsu
Name:	phospholipase A2, group VI; targeted mutation 1, Yoshihide Tsujimoto
MGI ID:	MGI:3777373
Synonyms:	iPLA2beta-
Gene:	Pla2g6  Location: Chr15:79170428-79212590 bp, - strand  Genetic Position: Chr15, 37.7 cM
Alliance:	Pla2g6tm1Tsu page

Germline Transmission:	Earliest citation of germline transmission: J:132853
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 9 was replaced with a neomycin resistance cassette. Immunoblot of testicular lysates indicated no protein expression of the targeted locus occurred in homozygotes. (J:132853)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pla2g6 Mutation:	65 strains or lines available

Original:	J:132853 Shinzawa K, et al., Neuroaxonal dystrophy caused by group VIA phospholipase A2 deficiency in mice: a model of human neurodegenerative disease. J Neurosci. 2008 Feb 27;28(9):2212-20
All:	6 reference(s)