Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Sp6tm1Yoya Name: trans-acting transcription factor 6; targeted mutation 1, Yoshihiko Yamada MGI ID: MGI:3775913 Synonyms: Epfn- Gene: Sp6  Location: Chr11:96904395-96915565 bp, + strand  Genetic Position: Chr11, 60.51 cM Alliance: Sp6tm1Yoya page

Defective tooth formation in Sp6tm1Yoya/Sp6tm1Yoya mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:132157
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exon 2, which contains the entire coding region, was replaced by a neo cassette. (J:132157)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp6 Mutation:	18 strains or lines available

Original:	J:132157 Nakamura T, et al., Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number. J Biol Chem. 2008 Feb 22;283(8):4825-33
All:	7 reference(s)