Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdpntm1Acgg
Name:	podoplanin; targeted mutation 1, Adriana C Gittenberger-De Groot
MGI ID:	MGI:3775822
Gene:	Pdpn  Location: Chr4:142994001-143026134 bp, - strand  Genetic Position: Chr4, 77.29 cM
Alliance:	Pdpntm1Acgg page

Germline Transmission:	Earliest citation of germline transmission: J:132132
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 4 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on E13.5 whole embryo extracts. (J:132132)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdpn Mutation:	28 strains or lines available

Original:	J:132132 Mahtab EA, et al., Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Dev Dyn. 2008 Mar;237(3):847-57
All:	7 reference(s)