Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aplntm1Ntak
Name:	apelin; targeted mutation 1, Nobuyuki Takakura
MGI ID:	MGI:3775290
Gene:	Apln  Location: ChrX:47114023-47123730 bp, - strand  Genetic Position: ChrX, 25.48 cM, cytoband A3.2
Alliance:	Aplntm1Ntak page

Germline Transmission:	Earliest citation of germline transmission: J:131824
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3.1 kb fragment including all of exon 2 was replaced with a neo cassette via homologous recombination. (J:131824)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apln Mutation:	13 strains or lines available

Original:	J:131824 Kidoya H, et al., Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J. 2008 Feb 6;27(3):522-34
All:	10 reference(s)