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Del(14Ltb4r2-Ltb4r1)1Bodd
Targeted Allele Detail
Summary
Symbol: Del(14Ltb4r2-Ltb4r1)1Bodd
Name: deletion, Chr 14, Bodduluri Haribabu 1
MGI ID: MGI:3775059
Synonyms: BLT1/BLT2-, Del1Bodd, Ltb4r1/Ltb4r2tm2Bodd
Gene: Del(14Ltb4r2-Ltb4r1)1Bodd  Location: unknown  Genetic Position: Chr14, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131779
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(14Ltb4r2-Ltb4r1)1Bodd involves 2 genes/genome features (Ltb4r2, Ltb4r1) View all
 
Mutation details6 Kb of the coding region and the untranscribed region between both open reading frames were replaced with an EGFP-neo cassette. The absence of transcript from either open reading frame was confirmed by northern blot analysis on spleen, liver, neutrophil and macrophage extracts. (J:131779)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(14Ltb4r2-Ltb4r1)1Bodd Mutation:  1 strain or line available
References
Original:  J:131779 Shao WH, et al., Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice. J Immunol. 2006 May 15;176(10):6254-61
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory