Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpc1tm1.1Alan
Name:	glypican 1; targeted mutation 1.1, Arthur Lander
MGI ID:	MGI:3774029
Gene:	Gpc1  Location: Chr1:92759367-92787933 bp, + strand  Genetic Position: Chr1, 46.6 cM
Alliance:	Gpc1tm1.1Alan page

Germline Transmission:	Earliest citation of germline transmission: J:130809
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 1, containing the translation initiation site and signal sequence, and the 5' end of intron 1 have been removed by Cre recombinase mediated recombination, leaving a single loxP site. The authors state that no protein expression was detected. (J:130809, J:159598)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gpc1 Mutation:	27 strains or lines available

Original:	J:130809 Aikawa T, et al., Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells. J Clin Invest. 2008 Jan;118(1):89-99
All:	5 reference(s)