Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Robo1tm1Wian
Name:	roundabout guidance receptor 1; targeted mutation 1, William Andrews
MGI ID:	MGI:3772898
Synonyms:	Dulox Robo-, Robo1-
Gene:	Robo1  Location: Chr16:72105194-72842983 bp, + strand  Genetic Position: Chr16, 41.08 cM
Alliance:	Robo1tm1Wian page

Germline Transmission:	Earliest citation of germline transmission: J:130430
Parent Cell Line:	CCB (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: In a two step integration process a hyg cassette with a 5' loxP site was inserted upstream of exon 1 and a puromycin resistance cassette with a 3' loxP site was inserted upstream of exon 22. Cre-mediated recombination was used to delete exons 1 through 21. The absence of protein expression was confirmed by immunohistochemistry. (J:130430)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Robo1 Mutation:	87 strains or lines available

Original:	J:130430 Andrews W, et al., The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons. Dev Biol. 2008 Jan 15;313(2):648-58
All:	12 reference(s)