Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plagl2tm1Wjmv
Name:	pleiomorphic adenoma gene-like 2; targeted mutation 1, Wim J M Van de Ven
MGI ID:	MGI:3771822
Synonyms:	PlagL2-
Gene:	Plagl2  Location: Chr2:153069689-153083278 bp, - strand  Genetic Position: Chr2, 75.41 cM, cytoband H2
Alliance:	Plagl2tm1Wjmv page

Germline Transmission:	Earliest citation of germline transmission: J:130260
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was preplaced with a lacZ and floxed neo cassette flanked by frt sites. Cre-mediated recombination was used to excise concatamers. The absence of the endogenouse transcript and the presence of the fusion transcript was confirmed by RT-PCR on E16.5 and newborn mouse extracts. (J:130260)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	61 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plagl2 Mutation:	24 strains or lines available

Original:	J:130260 Van Dyck F, et al., Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007 Nov;6(5):406-13
All:	2 reference(s)