Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arhgef1tm1Djle
Name:	Rho guanine nucleotide exchange factor 1; targeted mutation 1, David J Lerner
MGI ID:	MGI:3769502
Synonyms:	Lsc-
Gene:	Arhgef1  Location: Chr7:24602337-24626019 bp, + strand  Genetic Position: Chr7, 13.52 cM
Alliance:	Arhgef1tm1Djle page

Germline Transmission:	Earliest citation of germline transmission: J:129331
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 1370 nucleaotide upstream of the start codon through the first 13 exons was replaced with a neo cassette eliminating the first 420 amino acids of the protein. The absence of protein was confirmed by western blot analysis on splenocyte and neutrophil extracts. (J:129331)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef1 Mutation:	73 strains or lines available

Original:	J:129331 Francis SA, et al., Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood. 2006 Feb 15;107(4):1627-35
All:	4 reference(s)