Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sphk2tm1Npa
Name:	sphingosine kinase 2; targeted mutation 1, Novartis Pharma AG
MGI ID:	MGI:3769486
Synonyms:	SK2-, Sphk2-
Gene:	Sphk2  Location: Chr7:45358891-45367426 bp, - strand  Genetic Position: Chr7, 29.45 cM
Alliance:	Sphk2tm1Npa page

Germline Transmission:	Earliest citation of germline transmission: J:129314
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	BALB/c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 6 were replaced with a neo cassette. The lack of transcript expression was confirmed by quantitative real-time PCR on extracts from kidney, liver, and brain. (J:129314)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sphk2 Mutation:	38 strains or lines available

Original:	J:129314 Zemann B, et al., Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood. 2006 Feb 15;107(4):1454-8
All:	9 reference(s)