Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Seletm2Alb
Name:	selectin, endothelial cell; targeted mutation 2, Arthur L Beaudet
MGI ID:	MGI:3767067
Synonyms:	E/P-
Gene:	Sele  Location: Chr1:163875773-163885246 bp, + strand  Genetic Position: Chr1, 71.35 cM
Alliance:	Seletm2Alb page

Germline Transmission:	Earliest citation of germline transmission: J:33135
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence extending from within exon 4 through a portion of 6 was replaced by an hprt minigene inserted by homologous recombination. This plasmid construct was electroporated into AB2.1 ES cells carrying a P-selectin (Selp) mutation (J:24239) and clones with the two mutations in cis were used to produce Sele/Selp double mutants. (J:33135)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sele Mutation:	51 strains or lines available

Original:	J:33135 Bullard DC, et al., Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med. 1996 May 1;183(5):2329-36
All:	29 reference(s)