Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fbxl20tm1Seto
Name:	F-box and leucine-rich repeat protein 20; targeted mutation 1, Mitsutoshi Setou
MGI ID:	MGI:3765911
Gene:	Fbxl20  Location: Chr11:97973382-98041229 bp, - strand  Genetic Position: Chr11, 61.69 cM
Alliance:	Fbxl20tm1Seto page

Germline Transmission:	Earliest citation of germline transmission: J:127941
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 and part of exon 4 were replaced by a neo cassette resulting in the loss of the F-box domain and a frame shift. The loss of protein product was confirmed by western blot analysis on hippocampus extracts. (J:127941)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxl20 Mutation:	33 strains or lines available

Original:	J:127941 Yao I, et al., SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell. 2007 Sep 7;130(5):943-57
All:	4 reference(s)