Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd4tm1Doi
Name:	CD4 antigen; targeted mutation 1, Christophe Benoist and Diane Mathis
MGI ID:	MGI:3765235
Synonyms:	LAG0CD40
Gene:	Cd4  Location: Chr6:124841655-124865184 bp, - strand  Genetic Position: Chr6, 59.17 cM
Alliance:	Cd4tm1Doi page

Germline Transmission:	Earliest citation of germline transmission: J:33272
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: ES cells containing a previously targeted Lag3 allele (Lag3tm1Doi) were targeted again with a vector replacing part of exon 5 of the Cd4 gene with a hygromycin selection cassette. Detection of doubly mutant embryos was determined by PCR and Southern blotting. (J:33272)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:	82 strains or lines available

Original:	J:33272 Miyazaki T, et al., LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice. Int Immunol. 1996 May;8(5):725-9
All:	1 reference(s)