Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myt1tm1.1Ggu
Name:	myelin transcription factor 1; targeted mutation 1.1, Guoqiang Gu
MGI ID:	MGI:3765056
Gene:	Myt1  Location: Chr2:181405125-181469590 bp, + strand  Genetic Position: Chr2, 103.77 cM
Alliance:	Myt1tm1.1Ggu page

Germline Transmission:	Earliest citation of germline transmission: J:127471
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Myt1tm1Ggu mice were crossed with Tg(Sox2-cre)1Amc mice, excising the floxed exon (exon 9 for long transcript of gene, exon 3 for short transcript) in the germline. Inactivation of the gene was confirmed by ISH and RT-PCR of the pancreas in E18.5 embryos. (J:127471) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	82 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myt1 Mutation:	57 strains or lines available

Original:	J:127471 Wang S, et al., Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910
All:	1 reference(s)