Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Mc2rtm1Dchi Name: melanocortin 2 receptor; targeted mutation 1, Dai Chida MGI ID: MGI:3764974 Synonyms: MC2R- Gene: Mc2r  Location: Chr18:68539978-68562391 bp, - strand  Genetic Position: Chr18, 41.89 cM Alliance: Mc2rtm1Dchi page

Histological analysis of the adrenal gland of Mc2rtm1Dchi/Mc2rtm1Dchi mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:127445
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region contained within exon 4 was replaced with a PGK-neo cassette. RT-PCR confirmed the absence of transcript in extracts from the adrenal gland. (J:127445)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mc2r Mutation:	21 strains or lines available

Original:	J:127445 Chida D, et al., Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18205-10
All:	7 reference(s)