Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bnip3tm1Gwd
Name:	BCL2/adenovirus E1B interacting protein 3; targeted mutation 1, Gerald W Dorn II
MGI ID:	MGI:3764664
Synonyms:	Bnip3-
Gene:	Bnip3  Location: Chr7:138492565-138511235 bp, - strand  Genetic Position: Chr7, 82.95 cM, cytoband F5
Alliance:	Bnip3tm1Gwd page

Germline Transmission:	Earliest citation of germline transmission: J:127533
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a floxed neo cassette leading to a protein truncation prior to the BH3 and transmemebrane domains. The absence of protein product was confirmed by western blot analysis. (J:127533)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bnip3 Mutation:	23 strains or lines available

Original:	J:127533 Diwan A, et al., Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest. 2007 Oct;117(10):2825-33
All:	14 reference(s)