About   Help   FAQ
Zpbptm1Zuk
Targeted Allele Detail
Summary
Symbol: Zpbptm1Zuk
Name: zona pellucida binding protein; targeted mutation 1, Martin M Matzuk
MGI ID: MGI:3762589
Synonyms: Zpbp1-, Zpbp1tm1Zuk
Gene: Zpbp  Location: Chr11:11229626-11412408 bp, - strand  Genetic Position: Chr11, 6.76 cM, cytoband A2
Alliance: Zpbptm1Zuk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126661
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a PgkHPRT cassette via homologous recombination. This resulted in deletion of the signal peptide encoding region. Northern and Western blot analysis confirmed the absence of RNA transcript and protein in the testes. (J:126661)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zpbp Mutation:  18 strains or lines available
References
Original:  J:126661 Lin YN, et al., Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Mol Cell Biol. 2007 Oct;27(19):6794-805
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory