Tnfsf12tm1.1Biib
Targeted Allele Detail
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| Symbol: |
Tnfsf12tm1.1Biib |
| Name: |
tumor necrosis factor (ligand) superfamily, member 12; targeted mutation 1, Biogen Idec |
| MGI ID: |
MGI:3762372 |
| Synonyms: |
TWEAK-, TWEAK knockout |
| Gene: |
Tnfsf12 Location: Chr11:69577076-69586675 bp, - strand Genetic Position: Chr11, 42.86 cM, cytoband B4
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| Alliance: |
Tnfsf12tm1.1Biib page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:126416
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP-flanked neomycin resistance cassette replaced the first three exons of the gene. The neo cassette was removed by breeding heterozygotes with Cre-transgenic mice. Absence of gene expression was confirmed by RT-PCR and Northern blot analysis.
(J:126416)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tnfsf12 Mutation: |
104 strains or lines available
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| Original: |
J:126416 Campbell S, et al., Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells. J Immunol. 2006 Feb 1;176(3):1889-98 |
| All: |
18 reference(s) |
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Analysis Tools
