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Brca1tm1.1Brn
Targeted Allele Detail
Summary
Symbol: Brca1tm1.1Brn
Name: breast cancer 1, early onset; targeted mutation 1.1, Anton Berns
MGI ID: MGI:3762184
Synonyms: Brca1delta
Gene: Brca1  Location: Chr11:101379590-101442781 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Alliance: Brca1tm1.1Brn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126551
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 5 through 13 were removed by cre-mediated expression following expression of a transient cre vector. Southern blot analysis on genomic DNA confirmed the genomic modification. (J:126551)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  113 strains or lines available
References
Original:  J:126551 Liu X, et al., Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory