Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Maddtm1Ytk
Name:	MAP-kinase activating death domain; targeted mutation 1, Yoshimi Takai
MGI ID:	MGI:3762127
Synonyms:	Rab3 GEP-
Gene:	Madd  Location: Chr2:90967705-91013404 bp, - strand  Genetic Position: Chr2, 50.46 cM
Alliance:	Maddtm1Ytk page

Germline Transmission:	Earliest citation of germline transmission: J:126869
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The 3' half of exon 1 through the 5' half of exon 2 was replaced with a neo cassette. The lack of protein expression was confirmed by western blot analysis on protein extracted from the brain. (J:126869)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Madd Mutation:	89 strains or lines available

Original:	J:126869 Tanaka M, et al., Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell. 2001 May;12(5):1421-30
All:	2 reference(s)