Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Serpinb1atm1.1Cben
Name:	serine (or cysteine) peptidase inhibitor, clade B, member 1a; targeted mutation 1, Charaf Benarafa
MGI ID:	MGI:3761627
Synonyms:	serpinb1
Gene:	Serpinb1a  Location: Chr13:33026075-33035168 bp, - strand  Genetic Position: Chr13, 13.75 cM, cytoband A4
Alliance:	Serpinb1atm1.1Cben page

Germline Transmission:	Earliest citation of germline transmission: J:125918
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A loxP site was introduced into intron 6 and a floxed Hyg-TK selection cassette into intron 7. Exon 7 and the selection cassette were removed by transient Cre expression, leaving a single loxP site behind. Western blot analysis on bone marrow neutrophils from homozygote mice indicated there was no expression of the wild-type allele. (J:125918)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Serpinb1a Mutation:	28 strains or lines available

Original:	J:125918 Benarafa C, et al., The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection. J Exp Med. 2007 Aug 6;204(8):1901-9
All:	15 reference(s)