Cyldtm1.1Awai
Targeted Allele Detail
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| Symbol: |
Cyldtm1.1Awai |
| Name: |
CYLD lysine 63 deubiquitinase; targeted mutation 1.1, Ari Waisman |
| MGI ID: |
MGI:3761624 |
| Synonyms: |
CYLDex7/8 |
| Gene: |
Cyld Location: Chr8:89423675-89478573 bp, + strand Genetic Position: Chr8, 43.51 cM
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| Alliance: |
Cyldtm1.1Awai page
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Enlarged spleen and Peyer's patches in Cyldtm1.1Awai/Cyldtm1.1Awai mice
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:126113
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: Exon 7 was removed by cre-mediated recombination and results in an out of frame translation. The absence of a wild-type allele in mouse embryonic fibroblasts was confirmed by RT-PCR using primers located in exon 6 and 9. However, higher levels of an alternative splice form without exons 7 and 8, which is missing the TRAF2 and NEMO binding sites, are produced.
(J:126113)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cyld Mutation: |
43 strains or lines available
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| Original: |
J:126113 Hovelmeyer N, et al., Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. J Exp Med. 2007 Oct 29;204(11):2615-27 |
| All: |
6 reference(s) |
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Analysis Tools
